BIO310H5 Lecture Notes - Lecture 19: Cytochrome B5 Reductase, Hbb, Fetal Hemoglobin
Document Summary
1 liter of blood has: 3 ml (1. 5%) oxygen dissolved in plasma 197 ml (98%) oxygen bound to hemoglobin 200ml total. If cardiac output = 5 l/min amount of o2 to tissue = 5l/min x 200ml o2 /l= 1000ml / min. More than enough to meet resting o2 requirement. The only form of energy that it can do is glycolysis. 4n and 1 ferrous ion - easy to capture oxygen. Other part of heme is protein that covers it. 1 subunit of a hemoglobin - heme and hemoglobin. Each hemoglobin can bind to 1 oxygen molecule. Each hemoglobin can bind to 4 oxygen molecules. Hemoglobin can bind to oxygen = oxyhemglobin. Has a higher affinity to binding to hemoglobin, then co2 and o2. Is very toxic because it is taking over binding compared to co2 and o2. Together there is a process of oxidation.
