BIO310H5 Lecture Notes - Lecture 11: Artificial Cardiac Pacemaker, Pacemaker Potential, Adenylyl Cyclase

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16 Feb 2016
School
Department
Course
Lecture 12 the Heart and Circulation
General Plan of the Circulatory System


opropulsive organ
oAn arterial system that
oCapillaries,
ovenous system

central
circulation peripheral
circulation
Functions of the Circulatory System
oTransport of:


 !"#

oHomeostasis involved in regulation of:
$

oImmune reactions
Open circulation
o% open circulatory 
hemocoel"&'(&)#*
$'+
oHemolymph (insect blood) 
o,!
Closed circulation in vertebrates and some invertebrates ( Squid)
o-$.#
o-/'0&)

o !12
!3#
Pulmonary:,
4+
1*5
4+

,$

#.
+3#
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The heart
6(
*""
%

The myocardium #+
7
o%1#
6'3.

o,3
7

o%73
Electrical activity of the heart
o (systole) diastole#

o83

oNeurogenic and myogenic Pacemakers
93

The pacemaker 37
; #
#
:3;
+# #
#
%3
;#
Neurogenic Pacemaker cells: 17
#;3



9
Myogenic Pacemakers: 17
#;3.
6
9
333
3#
933

8#
oIonic basis of automaticity

<=
73#
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>7+

0 =3*
 :?@:#
 - "'#
" <7' ",'#
A B7'C
( D7*
Cardiac Pacemaker Cells
The rapid opening of
voltage-gated calcium
channels is responsible
for the rapid
depolarization phase.
Pacemaker potential
=3
7
#
7#
+
7#+

Repolarizing the membrane
leads to the opening of the
Na+ channels
B
=,E1


7
:
7
.



7

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