BIO315H5 Lecture Notes - Lecture 1: Molten Globule, Protein Folding, Alternative Splicing
26 Sep 2017
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Document Summary
Level of regulation of transcription: promoters, alternative splicing, inhibitors and. We have further avenues of regulations besides from dna to protein. The final protein enhancers product is also affected by protein folding. Many different types of chemical reactions are required to produce a properly folded protein from the information contained in a gene. Process of gene expression is not over when the sequence of amino acids is generated. To be useful to the cell, this new polypeptide must fold up into its unique 3d conformation, at the correct speed: (structure and function relationship is essential) Sum of all energetically favorable arrangements -> final folding protein. Can have the same gene and identical proteins coming together. Alternative splicing: 1 gene - 1 protein, spliced differently -> different proteins. But it takes several minutes to synthesize a protein of average size. As each protein domain emerges from the ribosome starting from the n-terminus. Within a few seconds it forms a molten globule.
