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Lecture 12

BIO315H5 Lecture 12: BIO315 – Lecture 12

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Hai- Ying Mary Cheng

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BIO315 Lecture 12
Intracellular Vesicular Transport
Maintenance of compartmental diversity
Each compartment has a unique set of membrane markers
Together, the secretory and endocytic pathways are made up of 10+ chemically distinct,
membrane-enclosed compartments
How does a particular compartment maintain or exclude certain markers from its
Coated Vesicles
Serves 2 functions:
Physical function to mold vesicle
Helps to select proteins that will go into that vesicle
Types of Coated Vesicles
3 major types:
1: clathrin-coated: mediate transport b/w golgi and plasma membrane
COPII coated:
COP1 coated: bud off of golgi and transport cargo to an earlier compartment
Clathrin coat assembly drives vesicle formation
Clathrin is the major protein component
Adaptor proteins: sandwiched b/w clathrin cage and membrane, help to select specific
cargos into transport vesicles and bind the clathrin coat to the membrane
Clathrin-coated vesicle formation
Adaptor protein interacts with both cargo receptor and specific lipids
Loss of interaction b/w adaptor proteins and membrane lipids - happens b/c vesicle may
have phospholipids that destroy that interaction
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