BIO315H5 Lecture Notes - Lecture 15: Covalent Bond, Mitosis, Treadmilling

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21 Dec 2014
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Don"t want things that break extremely easily when you don"t want them to: be potentially highly dynamic. You want to be able to disassemble easily. Properties of intermediate filaments: those above are examples of microtubules and actin which are made up of globular subunits. If the conc of the free subunits falls below the threshold, not get polymerization. It is only when the free subunit conc exceeds the critical concentration. *microtubules are made up of alpha and beta tubulin subunits. *actin filaments are only made up of 1 subunit and the subunit binds to atp not gtp. If we take a beaker and we have free subunits and we catalyze the polymerization. Treadmilling is a consequence of nucleotide hydrolysis: the green is a filament and we are taking a time lapse of the same area and watch how this filament changes in position.

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