BIO200H5 Lecture Notes - Lecture 6: Concentration, Coagulation, Extrapolation

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1 Dec 2013
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Distribution: how the molecule spread through the body to find target sites. Fill the water with molecules and eventually get to the target site. If you know volume and concentration, then this will tell you how to calculate other doses. Plasma - get rid of red and white blood cells, you"ll be left with plasma. It is essentially serum (plasma without the clotting factor) Plasma proteins are all over the vascular system. Bind to molecules and carry them around blood stream. This is an estimation of concentration of what the drug produced in the blood stream. Initial concentration cannot be measured (we can do serial concentrations over time, then extrapolate) Extrapolate by turning the graph into semi log form (this will straighten the curve) We take anti-log and plug into formula of dose/volume. Resembles a real aqueous compartment in the body. Parts of the body that will temporarily hold onto drugs. As [d] decrease, it will release the drug.

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