BIO200H5 Lecture Notes - Lecture 15: Loading Dose, Therapeutic Index, Diazepam
Document Summary
Hs - at bedtime (in the hour of sleep) Fixed ratio to the free [ ] = total plasma [ ] Lectures page 1 (kidney/ liver works more slowly) Change in [] over time is the fraction of c. Zero/ first order is fixed (does not depend on anything) Suppose we stop infusion, time of zero is also a plateau where drug is all gone. 5 x t1/2 to reach plateau for q2 t1/2 does not change regardless of where the plateau is. There is a low rate of infusion (q1) Ignore middle row (kt) f = how you"ve gone to a new plateau. Example: time elapsed = 2 x t1/2 for f=0. 75. Top of fluctuating graph is cmax, bottom is cmin. **f = first pass effect = 1 - e f=fractional attainment. Cther = is the dose that produces therapeutic effect (below graph) Ctox = is the dose that produces toxic effect (above the graph)
