BIO200H5 Lecture Notes - Lecture 8: Renal Physiology, Neostigmine, Digoxin
Document Summary
Clearance i - general principles: termination of drug action: what is tbc? (basic concept) Amount of body water (liters) entirely cleared of drug per unit time (hour, minute) Removal of unwanted molecules - endogenous or exogenous. Clearance tbc versus clh, clr (additive nature: organs involved in tbc. Calculations related to tbc k (elimination rate constant) (k = -2. 303 x slope) t (half life of drug) (t1/2 = 0. 693 / k) Vd (apparent volume of distribution) (v = d / co) New chart concentration versus time with ctox and. Clearance ii: the kidney/clearance by the kidney: introduction. = the major route of clearance for polar drugs and the polar metabolites of non-polar drugs. Eliminated in urine * expired air sweat saliva bile, etc. 3 processes: glomerular filtration (= 120 ml/min) (passive, tubular secretion (active transport, tubular reabsorption (mostly passive) Rate of renal excretion = rate of filtration + rate of secretion.
