Class Notes (839,087)
Canada (511,185)
Biology (2,156)
BIO203H5 (36)
Lecture 11

BIO204 Lecture 11

11 Pages

Course Code
Sanja Hinic- Frlog

This preview shows pages 1,2 and half of page 3. Sign up to view the full 11 pages of the document.
11 October-15-13 12:09 PM An overview of cellular respiration Two “Methods” of Producing ATP during Respiration Oxidative phosphorylation • Electrochemicalgradient produced by the ETC forces movement of protons back across the membrane • ATP synthase in membrane uses this energy to phosphorylate ADP to form ATP Substrate-level phosphorylation (Glycolysis and Krebs cycle) • ATP is produced by the enzyme catalyzed transfer of a phosphate group from an intermediate substrate to ADP Substrate level phosphorylation and free energy changes as glucose is oxidized GlycolyticReactions • Ten reactions of glycolysis occuring in cytosol • An energy investment phase of glycolysis uses two ATP • An energy payoff phase produces four ATP by substrate-levelphosphorylation • Net yield of glycolysis ○ 1 glucose -> 2 NADH,2 ATP, 2 pyruvate **Where it take place, how much ATP is produced, distinguish different types Glycolysisis regulated by feedback inhibition • Feedback inhibition ○ Inhibition of an enzyme in a pathway by the product of that pathway • High levels of ATP inhibit the enzyme phosphofructokinase ○ The product of this enzyme can be used only in glycolysis ○ Perfect regulation point Feedback Inhibition regulates metabolic pathways Pyruvate Processing • Pyruvate from glycolysis ○ transported from cytoplasm to mitochondria ○ Pyruvate processing occurs in mitochondrial matrix • Pyruvate dehydrogenase converts pyruvate to acetyl- CoA Regulation of pyruvate processing: ○ Positive and negative feedback control on Pyruvate dehydrogenase ○ Large supplies of products (NADH and acetyl-CoA) inhibit the enzyme complex ○ Large supplies of reactants (pyruvate) and low supplies of products (acetyl-CoA) stimulate processing Krebs Cycle Krebs Cycle • Carboxylic acids are oxidized in the Krebs cycle ○ H+ donors ○ Not one of them is used up • Citrate is first molecule in Krebs cycle ○ From pyruvate (from glycolysis) ○ Oxaloacetate (the last molecule in the cycle) • Kreb
More Less
Unlock Document

Only pages 1,2 and half of page 3 are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.