BIO315H5 Lecture Notes - Lecture 23: Basal Lamina, Cadherin, Integrin
Document Summary
Give some examples of aspects of organization, function and dynamics of an organism. What are the key features of cell junctions and the extracellular matrix: connective tissue, epithelial tissue. Explain connective tissue in terms of the cell junctions and extracellular matrix: ex. Explain junctions of the epithelial tissues: there are different types, such at the cell-cell or the cell-matrix, involve transmembrane adhesion proteins like cadherin (which is mainly cell to cell) and integrin which is mainly cell-matrix. It is not like glue, but it is highly selective. An example that illustrates this is when embryos are dissociated into single cells and the cells are mixed and then allowed to reassociate, the cells reassembled into structures resembling the original embryo which highlights a developmental role. There is also variable expression and tissue structures: in epithelial cells there is increased expression and in mesenchymal cells there is less expression but is more mobile (cancer cells often have cadherin mutations).
