BIO380H5 Lecture Notes - Lecture 20: Paraxial Mesoderm, Limb Bud, Lateral Plate Mesoderm
Document Summary
Slide 10: the hox genes are also required for patterning the digits. Shows you in this case that hox genes are required for the patterning and structure formation in developing limbs. If (cid:455)ou had a split i(cid:374) the icm, (cid:455)ou get : the cells in the limb bud are very plastic early on, each half of the limb bud can form an entirely new limb. If you remove parts of the limb disc, the limb will still form: the cells that are lost can be replaced by other cells, almost saying these limb discs are pluripotent, d. If you overlap 2 limb discs, too much material. It will still form only 1 limb: e. Frog has too many limbs: result from parasitic organism that form cists. If you imagine the parasites egg is breaking up that limb field, then you can see why the limb field is split up and formed multiple limbs.
