CHM333H5 Lecture Notes - Lecture 1: Enzyme, Alcohol Dehydrogenase, Thermodynamics
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100s => use of gold for treatment of old age in china => modern day use of sodium aurothiomalate for arthritis. Use of mercury oxides for treatment of syphilis. 1907s => use of pt for treatment of cancer (cisplatin or cis-pt(nh3)2cl2) **si and al are abundant in earth"s crust where they exist as oxides but not present in sea. Compare reduction of metal to prebiotic environment (-0. 32v) Metals with reduction value less than -0. 32 v prefer to be oxidized and remain in ionic form. Metals with reduction value greater than -0. 32 v tend to be reduced and in metal form. Hydrolases: peptidases (zn, mg) and phosphatases (zn, mg, cu) Oxido-reductases: oxidases (fe, cu), reductases (fe, cu, mo), nitrogenases (fe, mo) Most can assume coordination numbers greater than 4. Some can form clusters to facilitate multielectron processes. Why are specific inorganic elements required for particular biological functions and hence essential to.
