PSY397H5 Lecture Notes - Lecture 8: Dlg4, Potassium Channel, Calcium Signaling
Document Summary
Three-way coincidence detection (slide 18: strong input: glutamatergic synaptic stimulation, modulatory input: cholinergic synapse leading to activation of pkc modifying kv4. 2 function leading to limitation of k+ outflux causing facilitation of back propagating action potentials, kv4. 2: potassium channel. If potassium channel is closed, then cholinergic synapse will strengthen: weak glutamatergic synaptic connection leading to strengthening due to enhanced bp ap. Cytoskeletal processes: scaffolding, trafficking of molecules, anchoring of molelcules. Integrins: transmembrane signaling: n-cadherin: shape of synapse. Remember that the neuron is not like a liquid filled bowl; it has a lot of structural elements that play roles in processes. Psd-95 as an anchoring protein for nmda receptors. Need to know that actin is located in the muscles. Important to synaptic infrastructure and function anchoring protein. Post synaptic terminal sends retrograde message to presynaptic terminal. Post and pre-synaptic terminals are kept physically binded together by the integrins.
