PSY397H5 Lecture 4: Lecture 5 .pdf
Document Summary
Ltd: but both ltp and ltd is associated with intracellular ca2+ concentration, the increase is larger in ltp than in ltd. a sudden increase of. Mechanisms upstream of the nmda receptor that directly regulate. Large number of molecular players interact to achieve a complex temporal and input specific integration of signals: information processing at the synapse level. Pkc, pka: fine tuning of how much stimulation is required for a given level of calcium influx, and how much calcium will enter the cell after a given amount of stimulation will determine whether synapse undergoes. Ltp or ltd: fine tuning of how long the nmda-r stays in an activatable state will also influence its ability to temporally integrate signals. Husi et al. (2001) nature neuroscience 3: 661-669. Mechanism tyrosine phosphorylation loss of zn inhibition binding scaffolding ser/thr phosphoryation (direct) src activation (indirect) phosphorylation dephosphorylation ser/thr phosphorylation sulfhydryl nitrosylation or oxidation.
