PSY355H5 Lecture Notes - Embryonic Stem Cell, Gene Knockout, Neomycin
Document Summary
11/20/2013 1:56 pm don"t know if phenotypical change from knockout is due to change in function of the mouse"s brain. 1: lecture 7: transgenic + knockout mice many diff. types of reverse genetics techniques. Down"s syndrome: genetic disease but not heritable, mother doesn"t carry gene, chromosomal abnormality happens in her body, always comes from mother. 16th chromosome on mouse related to 21st chromosome on human genome. 4: fragile x syndrome: x chromosome easy to break using cytology, people behave like autistic patients. 5: can make a transgenic mouse for only couple now, used to be bigger deal. Dna bound to histone is silenced and unable to send mrna to be processed. Mutations changes in dna sequence, may be large or small scale large ones = gain/loss of chromosomal regions = translocations small scale: happens at nucleotide base substitutions, deletions, or insertions.
