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Lecture

Long-term potentiation.docx

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Department
Psychology
Course
PSY397H5
Professor
Robert Gerlai
Semester
Fall

Description
15-10-2013 Tuesday Long-term potentiation  Established by glutamatergic synapse  Flashbulb memory: rise in activity of modulatory inputs acting on and primes pyramidal cells  LTP: structural modification of the synapse, post and presynaptic terminals gets physically modified. However:  Memory upon recall is a constantly dynamic process (I have to rebuild the house). Therefore any memory can be inaccurate; things get added and removed from it (it can be built quite different). It is never 100% accurate. If left alone it doesn’t get modified and remains intact.  Reconsolidation: process of memory access that makes the memory prone to change.  LTP: the process by which the pyramidal cells can label memory pieces in cortical regions and therefore able to consolidate acquired memory (11:20)  Synaptic connections related to a single episode.  When a memory gets activated the connection gets strengthened.  Cells that fire together wire together. “Hebb’s”  We have no idea how the molecular changes leads to the behavioural changes.  Single pulse stimulatio
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