ANTB15H3 Lecture Notes - Hemolytic Disease Of The Newborn, Globulin, Valentina Vostok
Document Summary
Classical genetic markers: simple inheritance (one gene, no environmental modification, easily scored and recognized, vary from population to population (polymorphic 2 or more alleles in the system) example: abo blood group system. All classical genetic markers are mendelian traits, but not all mendelian traits make good genetic markers. Mn system and s= mns system: gene loci closely linked on 4th chromosome, therefore genes transmitted as ns, no antibodies for mn system. The duffy blood group: two co-dominant genes for presence of antigen, natural selection in malaria prevalent areas. Fy4 antigen does not have attachment for vivax: est. Degree of admixture of european and african descent. Allows you to make a, b, or ab. If you are homozygous (h/h), you will not display any of your blood type -> you"ll simply be old. This particular genotype is called bombay blood type, discovered in bombay.
