BIOA01H3 Lecture Notes - Lecture 2: Eukaryote, Nuclear Pore, Purine
26 Nov 2012
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Who figured out the structure of dna: watson and crick. Historical reasoning behind why dna is important and a hereditary material: Early microscope noticed that when a sperm fertilized an egg only a part of the sperm that entered the egg was the nucleus. Thus, scientists were certain that hereditary material was either in protein or nucleic acids. Frederick griffith found a substance that could genetically transform pneumonia bacteria. Griffith"s goal: make a vaccine to prevent pneumonia. Experiment: studied the conversion of nonvirulent r form bacteria to a (infective) s form bacteria: s form: had a capsule surrounding the cell, having smooth shiny colonies, r form: no capsule, thus rough and non shiny. Objective: injected bacteria into mice and determined how they were affected. Transformation: conversion of r bacteria to s bacteria. Transforming principle: agent responsible for transforming r to s bacteria. Agent responsible for transforming r to s bacteria: proteins and nucleic acids.
