BIOA01H3 Lecture Notes - Lecture 2: G1 Phase, Extracellular Fluid, Molecular Genetics

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Watson and crick correctly figured out that the sugars and phosphates formed a backbone" for the strand of dna and the nitrogenous bases lined up facing the other direction. This immediately suggested that nitrogenous bases served as a code. Watson and crick proposed dna is usually found as two polymers (two strands) held together to form a dna helix. As nitrogenous bases pair up with hydrogen bonds. One function of the nitrogenous bases is to form hydrogen bonds with the nitrogenous bases of another dna, which promotes formation of double stranded structure. Dna must be ordered anti-parallel: this means free phosphate group at the top of one strand and bottom of the other, oh group is at the bottom of one strand and at top of the other. While hydrogen bonds are weak individually, collectively they are very strong and hold the dna together. One strand of dna is very stable because of covalent bonds.

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