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Lecture 10

BIOA01H3 Lecture Notes - Lecture 10: Nuclear Localization Sequence, Endoplasmic Reticulum, Nuclear Pore


Department
Biological Sciences
Course Code
BIOA01H3
Professor
Mark Fitzpatrick
Lecture
10

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Endomembrane System of a Eukaryotic Cell
o Structures included:
Nuclear envelope
Endoplasmic reticulum
Golgi apparatus
Lysosomes
Plasma membrane
Vesicles
o Exocytosis
Vesicle buds off from the endomembrane system and fuses with the plasma
membrane. It then delivers its content into the extracellular space
o Endocytosis
Material from the outside of the cell is brought into a vesicle that can then fuse
with other organelles
Parts of the Cell
1. Nucleus
Stores DNA
Site of replication
Site of transcription
Assembling and transport of ribosomes out of the nucleus
Nuclear envelope defines the boundary of the nucleus
Consists of two layers (inner and outer)
Nuclear membrane is perforated by protein openings called nuclear pores
Allow for molecules to move into and out of the nucleus
These pores are essential for the nucleus to communicate with the rest of
the cell
Movement of proteins into the nucleus requires a nuclear localization
signal found within the protein sequence
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