Class Notes (1,100,000)
CA (650,000)
UTSC (30,000)
BIOA01H3 (800)
Lecture 12

BIOA01H3 Lecture Notes - Lecture 12: Intermediate Filament, Microfilament, Dynein


Department
Biological Sciences
Course Code
BIOA01H3
Professor
Mark Fitzpatrick
Lecture
12

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BIOA01H3
Cytoskeleton
o Three major protein components
Microtubules
A hollow tube formed from tubulin dimers
Kinesin and dynein motor proteins in microtubules cause movement
Helps with cell shape and support
Has functions in cell division
Microfilaments
A double helix of actin monomers
Critical to maintaining the unique shape of red blood cells
Myosin motor protein in microfilaments cause movement
Functions in muscle contraction
Intermediate filaments
A strong fiber composed of intermediate filament protein subunits
Polymers combine to form strong, cable-like structures in the cells,
providing mechanical strength
Over 100 different kinds of intermediate filaments
Extracellular Matrix
o An insoluble meshwork composed of proteins and polysaccharides
o There are many different forms of extracellular matrices
o Present in both plants and animals
Contributes to the structural support
Provides informational cues (role in signalling) that determine the activity of the
cells that are in contact with it
Collagen
o Collagen is the most abundant protein in the extracellular matrix of animals
o There are more than 20 different forms of collagen
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