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Lecture 12

BIOA01H3 Lecture Notes - Lecture 12: Intermediate Filament, Microfilament, Dynein

Biological Sciences
Course Code
Mark Fitzpatrick

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o Three major protein components
A hollow tube formed from tubulin dimers
Kinesin and dynein motor proteins in microtubules cause movement
Helps with cell shape and support
Has functions in cell division
A double helix of actin monomers
Critical to maintaining the unique shape of red blood cells
Myosin motor protein in microfilaments cause movement
Functions in muscle contraction
Intermediate filaments
A strong fiber composed of intermediate filament protein subunits
Polymers combine to form strong, cable-like structures in the cells,
providing mechanical strength
Over 100 different kinds of intermediate filaments
Extracellular Matrix
o An insoluble meshwork composed of proteins and polysaccharides
o There are many different forms of extracellular matrices
o Present in both plants and animals
Contributes to the structural support
Provides informational cues (role in signalling) that determine the activity of the
cells that are in contact with it
o Collagen is the most abundant protein in the extracellular matrix of animals
o There are more than 20 different forms of collagen
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