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CA (630,000)
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BIOA01H3 (800)
Lecture

BIOA01H3 Lecture Notes - Ribonucleotide, Nitrogenous Base, Intron


Department
Biological Sciences
Course Code
BIOA01H3
Professor
Mary Olaveson

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KEY TERMS:
EXON- region of the primary transcript that MIGHT be part of the final transcript of
RNA mol
INTRON- region of the primary transcript that are NEVER part of the final transcript if
there is no mistake. Sometime have a regulatory role in gene expression of OTHER
genes.
CAP- consists of a GTP nucleotide(guanine as nitrogenous base), such that the GTP
nucleotide’s free OH group off the third carbon’ is the face of the 5’ end and the
phosphate groups of the GTP are adjacent to the 5’ free phosphate group of the first
ribonucleotide. BEFORE TRANSCRIPTION IS FINISHED
5’ UTR 3’UTR- doesn’t contain info for translation to make protein
POLY(A)TAIL- small polymer with nucleotides that have adenine, the tail is created
separately. NOT created using DNA as template. Gets added on ENZYMATICALLY,
cleaves off backend of mmRNA(stimulates rna polymerase to get out). Happens as
transcription is terminating.
SPLISOSOMES: cut out introns, complex structure in RNA and protein components.
SPLICING PROCESS: recognizes specific RNA sequences bracketing the introns. There
are specific left and right boundary sequences. Works processively, first recognizes 5’
boundary until it finds 3’ boundary. Breaks of phosphodiester bonds holding intron to
extron and creates NEW phosphodiester bonds to link the (NOW) adjacent exons.
ALTERNATIVE SPLICING: produces alternative mRNA, more than one protein can be
made from one gene
TRANSLATION: process of making polypeptides using info encoded in mRNA(has
coded info to make protein) order of BASES of mRNA encodes info for ORDER of
amino acids of the protein
GENETIC CODE IS A TRIPLET CODE
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