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Lecture 14

BIOA01H3 Lecture Notes - Lecture 14: Atp Hydrolysis


Department
Biological Sciences
Course Code
BIOA01H3
Professor
Mark Fitzpatrick
Lecture
14

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Sanchika K
Nov.-23-10
Final Exam Notes Biology
Biology
Chapter 5: The Dynamic Cell Membrane
What are the Requirements for Life?
1.Supply of replicators- self-reproducing molecules
2.Replicator copy must be subject to error
3.Supply of free energy for metabolism/growth/reproduction/movement
4.Partial isolation from external environment
Why are membranes so important for Living Organisms?
Separate cell interior from external environment
Enclose cells and organelles inside cells
Responsible for selective permeability
Selection is really important allows for the ability of different concentration of material to
be found on different sides of the membrane
What is the structure of biological membranes?
Plasma membrane
Composed of 3 macromolecules
oLipids
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Sanchika K
Nov.-23-10
Final Exam Notes Biology
oProtiens
oCarbs
Key features
Lipids
Are insoluble in water
oNon polar hydrocarbon molecules go away from water
oHeld by weak hydrophobic forces
Major component of membranes
Phospholipids predominate
oPhosphate part is polar; hydrophilic
oFatty acid part is non-polar (uncharged) ; hydrophobic
oAmphipathic; membrane lipid has both hydrophobic and
hydrophilic part
oBi layer head is exposed to the outside tails are inside away from water
oSpontaneously orient themselves
Fluidity
oCrucial for function due to lipid
oPhospholipid can move laterally within the bilayer
Move, flip
oTypes of hydrocarbon tails
(unsaturated) less packed- leaky ; vegetable oil
saturated fatty acid tail (more packed)
oSteroid cholesterol
Has different effect on membrane fluidity at differ temp
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Sanchika K
Nov.-23-10
Final Exam Notes Biology
Good cholesterol made by body to keep membrane secure
Packs the spaced in unsaturated membrane
Membranes are more dynamic at temp; cholesterol fills the
space to prevent too much movement
Membrane Protein
Asymmetrically distributed in membrane
Can move freely within the bilayer or can be anchored to a specific region
Kinds/number vary amount different membranes
Involve in
oCatalyzing chemical rxn
oTransport processes
Types
oPeripheral- on 1 side of membrane only
oIntegral= trans membrane
Vertical transport
Carb
Oligosaccharide chains
Project from external surface of membrane
oGlycoproteins- attached to proteins
oGlycolipids- attach to phospholipids
Show considerable diversity and specificity
Function as a recognition signals between cells
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