BIOA01H3 Lecture Notes - Lecture 36: Contact Inhibition, Angiogenesis, Metastasis
13 May 2018
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Department
Course
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BIOA01
LEC 36 Viruses, and Cancer as a Genetic Disease
Dec 1, 2015
→Cell proliferation/apoptosis
- single zygote cell developing into a full human
- required for homeostasis
• apoptosis = cell suicide
- needed for development
- not all people go through apoptosis
- proliferation and apoptosis are linked and must occur with balance
- cancer develops through accumulation of mutations in somatic cells
→ Cancer → uncontrolled cell growth
- autocrine stimulation
- lose contact inhibition → cancer cells crowd on topo f each other even when
there are crowds
- loss of cell death
→ Cancer – Genomic and karyotypic instability
- defects in DNA replication machinery
- if you keep proliferating mistakes in mitosis occur
→ Cancer – immortality
- senescence
- normal cells cannot grow in culture
- cancer cells however can grow in culture→ do not need to sit on anything to
anchor
→ Cancer
- their ability to metastasize is what actually kills people
- cause damage in tissue and causes death
- tumour cells pick this up
- Angiogenesis → growth of blood vessels
→ Cell Cycle Control
- CDK (→ only function when cyclin is connected to them
→ Cyclin/CDK Control
***malignant neoplasms → cancers
→ Cancers are Genetic Diseases
- some cancers run in the family (hereditary) (only 10%)
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BIOA01H3 Full Course Notes
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Document Summary
Lec 36 viruses, and cancer as a genetic disease. Cell proliferation/apoptosis single zygote cell developing into a full human required for homeostasis: apoptosis = cell suicide. Proliferation and apoptosis are linked and must occur with balance cancer develops through accumulation of mutations in somatic cells. Autocrine stimulation lose contact inhibition cancer cells crowd on topo f each other even when there are crowds loss of cell death if you keep proliferating mistakes in mitosis occur. Normal cells cannot grow in culture cancer cells however can grow in culture do not need to sit on anything to anchor. Cancer their ability to metastasize is what actually kills people cause damage in tissue and causes death tumour cells pick this up. Cdk ( only function when cyclin is connected to them. Cancers are genetic diseases some cancers run in the family (hereditary) (only 10%)
