Lecture 11: Specialization and Chromatography

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Published on 17 Jun 2011
School
UTSC
Department
Biological Sciences
Course
BIOB10H3
Lecture 11: Cell Specializations
Sperm:
Function: SWIM! bind & dissolve egg coat
Cell Specializations:
1)Flagella: MTs and MT motors (ATPase)
2)Increase # of mitochondria = More ATP
3)Acrosome: secretory lysosomes: secreted via kinesin along MTs
Egg:
Function: Packed with mRNA (for transcription factors, etc) for early development, will initiate cell division shortly
after fertilization, can bind sperm.
Cell Specializations:
1)Increase #ribosomes- increase translation
2)Integrin: Binds to fertilin (on sperm)
3)Cell division: Mitotic spindle, contractile ring
4)Coating : Secretes protective proteins on outside.
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Neuron:
Cell Specializations:
1)Cell migration machinery: integrins, actin, Arp2/3
2)Nerve impulses Na/K pump, channels, etc
3)Increase mitochondria = Increase ATP
4)Secretion machinery: MTs (+MAPs) and kinesin, neurofillaments, actin and myosin V
Function: early in development: send out migratory axons towards target cells (synapses)
-after differentiation: nerve impulses and formation and secretion of secretory vesicles
Intestinal epithelial cell:
Functions: Secretion of digestive enzymes
-Absorption of digested contents
-Keeps digestive juices away from bloodstream
Cell Specializations:
1)Hemi-desmosomes: integrin attachement to basement membrane
2)Desmosomes: cadherins and IFs for mechanical strength
3)Tight Junctions: occluding and claudins: Seal
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4)Secretion machinery: ER/ Golgi secretory vesicles, MTs + kinesin
5) Microvilli: actin, fibrin, myosin I
Skeletal muscle :
Skeletal muscle cell development: fusion of many muscle cells
Function: contraction for body movements
Cell Specializations:
1)Contractile machinery: F-actin (thin filaments) and myson II (thick filaments) ATPase
2)Increase mitochondria= increase ATP
3)Sacromere needs increase Calcium -> increase extensive SER (sarcoplasmic reticulum)- Ca+ stores
Cardiac muscle :
Function: synchronized contraction to propel blood through heart
Cell Specializations:
1) Contractile machinery: F-actin (thin filaments) and Myosin II (thick filaments) ATP ase
2) Increase mitochondria= increase ATP
3) Sarcromere needs increase Ca increase extensive SER increase Ca+ storage
4) Gap junctions: connexion proteins forming connexion channel
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Document Summary

Cell specializations: flagella: mts and mt motors (atpase) Increase # of mitochondria = more atp: acrosome: secretory lysosomes: secreted via kinesin along mts. Function: packed with mrna (for transcription factors, etc) for early development, will initiate cell division shortly after fertilization, can bind sperm. Integrin: binds to fertilin (on sperm: cell division: mitotic spindle, contractile ring, coating : secretes protective proteins on outside. www. notesolution. com. Cell specializations: cell migration machinery: integrins, actin, arp2/3, nerve impulses na/k pump, channels, etc. Increase mitochondria = increase atp: secretion machinery: mts (+maps) and kinesin, neurofillaments, actin and myosin v. Function: early in development: send out migratory axons towards target cells (synapses) After differentiation: nerve impulses and formation and secretion of secretory vesicles. Cell specializations: hemi-desmosomes: integrin attachement to basement membrane, desmosomes: cadherins and if"s for mechanical strength, tight junctions: occluding and claudins: seal www. notesolution. com, secretion machinery: er/ golgi secretory vesicles, mts + kinesin, m icrovilli: actin, fibrin, myosin i.