BIOB10H3 Lecture Notes - Desmosome, Apoptosis, Endoplasmic Reticulum
15 Dec 2012
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Mts & mt motors (atpase: increased # of mitochondria atp, sperm receptor fertilin integrin protein, acrosome secretory lysosomes secreted via kinesin along mts, small cell with condensed streamlined head. Packed with mrna (for transcription factors etc. ) for early development. Will initiate cell division shortly after fertilization. Can bind sperm: big cell, big # ribosomes translation, integrin bind to fertilin, cell division. Keeps digestive juices away from bloodstream: hemi-desmosomes integrin attachment to basement membrane (with plectins & if"s, secretory machinery digestive enzymes . Er/golgi/secretory vesicles, mts + kinesin: microvilli actin, fimbrin, myosin i, tight junctions occludin & claudins seal. Provide continuously renewing, strong waterproof surface to protect body from environment. Wound healing: hemi- desmosomes integrins attachment to basement membrane (with plectin & if"s) Survival signals lose contact with ecm. Apoptosis, keratin release: desmosomes cadherin & if"s for mechanical strength, migrate over wound migration machinery. >- send out migratory axons towards target cells (synapses)
