BIOB10H3 Lecture Notes - Lecture 6: N-Terminus, Oogenesis, Nuclear Dna
25 Sep 2013
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Cellular uptake of particles and macromolecules: two separate categories: Phagocytosis: cell eating : uptake of relatively large particulate matter. (>0. 5 mm in diameter: for food, eg. unicellular heterotrophic protists, for protection, eg. , macrophage, neutrophil immune cells, entrapment (pseudopods) -> engulfment -> digestion -> absorption. Macrophage receptors on cell binds particle (bacteria, dead cells, etc. ) Macrophages have fc-receptors that binds to antibodies (igg) coating ( opsonize") pathogens. Phagocytosis by macrophages is induced in both innate(fast and first) and adaptive (antibody) immunity. Modes of bacteria escaping the lysosomes/phagosome: escape: listeria monocytogenes, prevent fusion with lysosomes: mycobacterium tuberculosis, survive in phagolysosome: coxiella burnetii. Uptake of proteins into peroxisomes: peroxisomes have only two compartments in which proteins can be placed. Internal matrix: proteins bound for peroxisome have peroxisomal targeting signal (pts, receptors bind to proteins in the cytosol and shuttle them to surface where receptor and ligand travel through peroxisome membrane to peroxisomematrix.
