BIOB10H3 Lecture Notes - Lecture 9: Cytoskeleton, Cytosol, Microtubule

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19 Nov 2018
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A: the cytosol contains water, ions, sugar etc. Also contains free ribosomes and lots of proteins (cytoskeletal proteins) Proteins are translated on free ribosomes in the cytosol and they stay there by default (there doesn"t need to be signal) The cytoskeleton: functions: provide structure and support =a scaffold, an internal framework that positions organelles. The cytoskeleton interacts and known how to position organelles: allows for the movement of materials and organelles within cells =intracellular transport, they are the machinery for cell division required for cell motility and cell functions -phagocytosis. Made up of 3 components: microtubules, microfilaments (actin filaments) The -tubulin is a -tubulin -tubulin heterodimer that hydrolyzes gtp at very slow rate but when the heterodimers are incorporated into a growing microtubule, its rate of gtp hydrolysis increases dramatically. A: the gap is the other -tubulin on the other heterodimer. The - tubulin is attached to proteins that are above the centrosome.

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