BIOB10H3 Lecture Notes - Lecture 3: Red Blood Cell, Beta Sheet, Sickle-Cell Disease

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16 Jul 2019
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Protein structure: protein structures are defined by 4 different levels of organization. Primary structures: the primary sequence is a specific sequence of amino acids determined by the sequence of the gene encoding the protein. There are 20 variations of proteins (20 amino acids). A typical protein is over 100 amino acids long so there is an infinite number of sequences possible. Sequences contain most of the information needed to specify 3-d shape and function of protein: changes in the primary structure can have dire consequences for protein function. An example of this is sickle cell anemia in which the shape of the red blood cell is affected. Due to this, arteries get clogged: there are 3 further levels of organization: secondary, tertiary and quaternary structure. For these structures to occur, proteins must fold. Secondary structures: the secondary structure shapes portions of the polypeptide chains. It is arranged to maximize the number of hydrogen bonds made between neighbouring amino acids.

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