BIOB10H3 Lecture Notes - Lecture 15: Neurospora Crassa, Transcription Bubble, Edward Tatum

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12 Sep 2016
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The relationship between genes and proteins was demonstrated by experiments done by. George beadle and edward tatum in 1940s: looked at growth of a bread mould: Neurospora crassa: hypothesized that if the dna of organism was damaged in some way, Certain genes may be mutated and hence not be able to express specific proteins. This would then make it difficult for the mould to grow under conditions where the function of that protein is critical. E. g. enzyme working in a specific metabolic pathway. We now know that we can"t simply go from a gene to make a protein: we require an intermediate known as mrna. Transcription: carried out by dna-dependent rna polymerases, carried out in the nucleus, pathway: Go from information storage (dna in nucleus) Several mrnas can be made from one molecule of dna. Each mrna can be made into large numbers of proteins / polypeptides: overview:

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