BIOB10Y3 Lecture 6: BIOB10 Lecture 6.docx

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Transport across plasma membrane: non polar substances, small substances can move through the bilayer. Facilitated diffusion is for large polar molecules, go through transporters (proteins that carry facilitated diffusion, high to low concentration) Active transport requires atp to push things across their concentration gradient, low to high. Endocytosis: bringing things in to destroy them (hydrolyze, breaks up macro molecules. Endocytosis is for substances that are too large. Includes: extracellular ligands, signal receptors that are no longer in use. Endocytosis: main time is receptor mediated endocytosis: uptake of specific extracellular macromolecules. Steps: ligand binds to the receptor, induces a conformational change that tells clatherin thers something needs to be brought in. forms an early endosome, brought in the ligand. clatherin falls off. Slow acidification causes the insulin to no longer have affinity to the receptor. So the receptor pinch"s off, and the insulin keeps going. The clathrin vesicles aren"t big enough for bigger particles.

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