BIOB11H3 Lecture Notes - Lecture 9: Nuclear Localization Sequence, Importin, Nuclear Pore
Document Summary
Sps: figs 12-1, 2, 6, 7, 8, 12. Vocabulary: nuclear pore complex/nuclear matrix/chromatin/nuclear envelope/ nucleoporins/ nuclear localization signal/importins/ histones/ nucleosomes/ scaffold/ topoisomerases. Talk about what will happen in the nucleus. The nucleus is a double membrane bound organelle but there is a lot of discontinuity within the membrane structure where membrane pores exist. At the membrane pore, transport is highly regulated. In the center of the nucleus there is a structure called the nucleolus where ribosomal genes are clustered, trnas and the beginnings of transcription occur. The cytoplasm or fluid-based part of the nucleus is called the nucleoplasm but there is also a structural framework of the nucleus referred to as the nuclear matrix. Chromatin is a general term which means a protein dna complex so basically talking about chromosomes when you are talking about chromatin. Some examples of chromatin associated proteins are transcription factors that associate with dna to help with transcription.
