BIOB11H3 Lecture Notes - Lecture 5: Snrnp, Ribonucleoprotein, U2Af2
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Forms the lariat: step 3: the (cid:1007)(cid:859) oh of e(cid:454)o(cid:374) (cid:1005) atta(cid:272)ks the (cid:1007)(cid:859) spli(cid:272)e site. Can go interact with other introns for splicing. The (cid:373) na (cid:858)fa(cid:272)tory(cid:859: ctd of the rna polymerase ii acts as a in capping, scaffold processing pre-mrnas polyadenylation, intron removal involved for the factors, mrna processing machinery travels with the polymerase as the transcript is being synthesized. Regulation of splicing: alternative splicing: splicing is regulated such that different versions of a mature mrna can be generated depending on the cellular needs. Small regulatory (non-coding) rnas: rna molecules are directly involved in the regulation of gene expression post transcriptional gene silencing, rna silencing: small rnas inhibit gene expression in various ways (sequence dependent, c. mello and a. The(cid:396)efo(cid:396)e : 20 amino acids (aa, four different nucleotides in mrna (a, u, g, c) If one nucleotide encodes for an amino acid 41 different aa (4) If two nucleotides encode for an amino acid 42 different aa (16)
