BIOB11H3 Lecture Notes - Lecture 9: Mitosis, Arginine, Lysine
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F phenylalanine, g glycine hydrophobic. Ran-gtp has an affinity for importin beta which results in a conformational change that releases the target molecule and the alpha subunit: exportins guide target molecule to the cytoplasm, ran-gtp is cleaved to ran-gdp. Chromosome packaging: during cell cycles, the chromatin and chromosomes are usually decondensed analogy of spaghetti, compact chromatin allows segregation analogy of breadstick, histones interact with naked dna = first step in packaging. Histones: h1 is larger than all the other histones, almost twice as big, are made up of arginine and lysine. Figure 12. 15: electron dense core scaffold at the bottom, loops of chromatin coming off from there, cohesion anchor the loops of chromatin to the protein scaffold. Figure 14. 14 when mitosis starts, condensin makes supercoiled loops. Type 1 topoisomerases = binds and creates a nick, alleviates tension, reseals nick. Type 2 topoisomerases = gate segment moves so that something can move through it, 2.
