BIOB11H3 Lecture Notes - Lecture 12: Response Element, Fibroblast, Cpeb
Document Summary
Figure 12. 17 calico cat: has orange and black regions amount varies, xist gene silences one of the x chromosomes (the xist gene = non coding rna and therefore does not make protein) Figure 12. 13: white lines = n-terminal tails/core histones that are on the edge of histones, their conformation can change. Figure 12. 18: various groups can be added or taken away (ex. phosphorylation, these alterations can cause changes in gene expression and chromatin structure. Figure 12. 47: complex binds to promoter elements, only if it was a specific affinity for it. Figure 12. 50: chromatin rewinding complex = swi/snf. Makes it more like naked dna: gtf - general transcription factors. Figure 12. 53 transcriptional repression: hdac removes deacetylated histones from nucleosomes. Figure 12. 57 alternative splicing in fruit flies: 1 gene gives many possibilities. Expands capacity of genome, can make more mrnas: entire fruit fly genome only has 14,000 genes.
