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Lecture 1

BIOB32H3 Lecture Notes - Lecture 1: Xerostomia, Daphnia, Citric Acid Cycle

Biological Sciences
Course Code
Steve Joordens

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BIOB32 Lecture 1
Slide 17
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- Link is given the syllabus
Slide 34
- Oldest
- Long interest in this
- Integrated function
o Understanding how things operate and resulting in an emergent
Slide 35
- Aristotle…
o Comparative… blood or no blood
- Erastristatus…
o He was the first to suggest that the heart operates as a pump
- Galen
o Defining relationship between structure and function
- Ibn…
Slide 36
- Lavoisier…
o The mouse and a candle in the jar
- Cannon
o Dry Mouth Hypothesis… What controls our sense of thirst?
Conducted an experiment that it was the dry mouth idea rather
than the stomach
3 groups of dogs, left alone, had a hole in their throat,
had a tube where water was poured into their throat
o Water that was poured into the throat, they were
still asking for more
o Hole in throat, stopped drinking after a while
because their mouth was no longer dry
Slide 38
- For every biological problem, there is an animal on which it can be most
conveniently studied
- Krebs cycle… studying the fly was crucial in understanding the krebs cycle….
o Mitochondria…. Is what is imperative to study krebs
o Flying is the most energetically expensive form of locomotion
- Bar headed goose…. These guys are exceptionally able to hypoxia adaptation
- Giraffe…. When a giraffe is feeding from a tree, blood needs to be pumped
way up its head and so there needs to be a huge blood pressure change
o Head lowered for drinking water but then the blood is rushing
downwards, and if the blood pressure was to stay the same as if it was
upright, there would be excess pressure and so this change in blood
pressure is most easily studied in girraffes
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