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Lecture

BIOB32H3 Lecture Notes - Biliverdin, Streptokinase, Fibrinolysis


Department
Biological Sciences
Course Code
BIOB32H3
Professor
Kenneth Welch

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Blood
The Cardiovascular System: An Introduction
The cardiovascular system
•Provides a mechanism for rapid transport of nutrients, waste products, respiratory gases and
cells
Functions and Composition of Blood
Blood
•Fluid connective tissue
•Functions include
•Transporting dissolved gases, nutrients, hormones, and metabolic wastes
•Regulating pH and ion composition of interstitial fluids
•Restricting fluid loss at injury sites
•Defending the body against toxins and pathogens
•Regulating body temperature by absorbing and redistributing heat
The composition of blood
•Plasma and formed elements comprise whole blood
•Red blood cells (RBC)
•White blood cells (WBC)
•Platelets
•Can fractionate whole blood for analytical or clinical purposes
Hemopoiesis
•Process of blood cell formation
•Hemocytoblasts are circulating stem cells that divide to form all types of blood cells
•Whole blood from anywhere in the body has roughly the same temperature, pH and viscosity
Plasma
•Accounts for 46-63% of blood volume
•92% of plasma is water
•Higher concentration of dissolved oxygen and dissolved proteins than interstitial fluid
Plasma proteins
•more than 90% are synthesized in the liver
•Albumins
•60% of plasma proteins
•Responsible for viscosity and osmotic pressure of blood
Additional Plasma Proteins
•Globulins
•~35% of plasma proteins
•Include immunoglobins which attack foreign proteins and pathogens
•Include transport globulins which bind ions, hormones and other compounds
•Fibrinogen
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