BIOB32H3 Lecture Notes - Phosphocreatine, Myosin Head, Endomysium

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Three types of muscle: skeletal attached to bone, cardiac found in the heart, smooth lines hollow organs. Skeletal muscle functions: produce skeletal movement, maintain posture and body position, support soft tissues, guard entrances and exits, maintain body temperature. Organization of connective tissues: epimysium surrounds muscle, perimysium sheathes bundles of muscle fibers, epimysium and perimysium contain blood vessels and nerves, endomysium covers individual muscle fibers, tendons or aponeuroses attach muscle to bone or muscle. Skeletal muscle fibers: sarcolemma (cell membrane, sarcoplasm (muscle cell cytoplasm, sarcoplasmic reticulum (modified er, t-tubules and myofibrils aid in contraction, sarcomeres regular arrangement of myofibrils. Myofibrils: thick and thin filaments, organized regularly. Thin filaments: f-actin, nebulin, tropomyosin, covers active sites on g-actin, troponin, binds to g-actin and holds tropomyosin in place. Thick filaments: bundles of myosin fibers around titan core, myosin molecules have elongate tail, globular head, heads form cross-bridges during contraction, interactions between g-actin and myosin prevented by tropomyosin during rest.

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