BIOB34H3 Lecture Notes - Bone Marrow, Erythropoiesis, Red Blood Cell

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20 Mar 2013
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Chapter 18 Blood
Blood Basics
- about 5 liters, about 8% of body weight
- pH ranges 7.35 - 7.45
- Is a connective tissue
1. formed elements
a. erythrocytes (RBCs)
b. leukocytes (WBCs)
c. platelets
2. matrix is plasma
- Functions
1. transport of O2, CO2, nutrients, wastes, heat, hormones
2. protection, from WBCs and other defenses
Plasma
- 55% of whole blood
- 90% water
- Contains proteins, ions, buffers, respiratory gases, nutrients, wastes, hormones
- Proteins are functionally important
1. establish osmotic pressure (holds water)
2. three main types
a. albumins- bind substances for transport
b. globulins- bind substances for transport, blood clotting, inactive precursor molecules,
antibodies
c. fibrinogen- blood clotting
Formation of Blood Cells (Hematopoiesis)
- Occurs in red marrow
Erythrocytes
- About 45% of whole blood
- Very small, about 8 m in diameter, can squeeze through even smaller capillaries
- About 5 million/mm3
- Mature cells have no nucleus or other organelles
- Make ATP anaerobically
- Live about 120 days, most die in spleen capillaries
- Contain hemoglobin
1. carries most of the oxygen
2. carries some carbon dioxide
3. helps buffer blood
- Erythropoiesis (production of RBCs)
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Document Summary

About 5 liters, about 8% of body weight. Is a connective tissue: formed elements, erythrocytes (rbcs, platelets leukocytes (wbcs, matrix is plasma. Functions: transport of o2, co2, nutrients, wastes, heat, hormones, protection, from wbcs and other defenses. Contains proteins, ions, buffers, respiratory gases, nutrients, wastes, hormones. Proteins are functionally important: establish osmotic pressure (holds water, three main types, albumins- bind substances for transport, globulins- bind substances for transport, blood clotting, inactive precursor molecules, antibodies fibrinogen- blood clotting. Occurs in red marrow: formation of blood cells (hematopoiesis, erythrocytes. Very small, about 8 m in diameter, can squeeze through even smaller capillaries. Mature cells have no nucleus or other organelles. Live about 120 days, most die in spleen capillaries. Contain hemoglobin: carries most of the oxygen, carries some carbon dioxide, helps buffer blood. Erythropoiesis (production of rbcs: controlled by hormone erythropoietin, which is released from the kidneys in response to low oxygen levels.

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