BIOB10Y3 Lecture Notes - Lecture 4: Lipid Bilayer, Membrane Lipids, Glycerophospholipid
29 Aug 2016
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Chapter 4 the structure and function of the plasma membrane. 4. 1 membrane functions: compartmentalization, scaffold for biochemical activities, providing a selectively permeable barrier, transporting solutes, responding to external stimuli. Overton (1890s) tested the permeability of the outer layer, placed plant roots hairs into solutions of solutes discovered that more lipid-soluble solutes rapidly enter the root hair cells. Gorter & grendel (1925) extracted lipid from human rbc"s and measured the amt of s. a. the lipid covers over the surface of water plasma membrane contained a lipid bilayer. Davson & danielli proposed the plasma membrane was composed of a lipid bilayer lined on both its inner & outer surface by globular proteins, the lipid bilayer was also penetrated by protein-lined pores (revised) 4. 3 chemical composition of membranes: membrane lipids. Phosphoglycerides: glycerol backbone, membrane glycerides are diglycerides, additional group linked to phosphate. Pc, pe, pi: head group water soluble, hydrophobic fatty acid chains.
