BIOB51H3 Lecture Notes - Lecture 8: Point Mutation, Negative Number, Escherichia Coli
2 Mar 2018
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Document Summary
Evolution of mutation rate: evolution by natural selection requires, variation, heritability of variation, fitness differences of heritable phenotypes, mutation rates depend on the accuracy of dna polymerase, which is for replication and repair. It also depends on the accuracy of dna polymerase which varies due to allelic variation. In the mutation accumulation experiment, most mutations tended to decrease fitness. Summary of mutation: the source of variation in populations, the most common type of mutation is point mutation which creates new alleles, a lot of genetic variation exists, mutation rates are variable and can evolve. Genetic variation and fitness: why doesn"t natural selection remove most genetic variation from populations, mutations add new genetic variants at every generation, the genotype linked to the most fit phenotype may vary. For example, genotype x environment: mutation provides heritable variation that is essential to evolution. It is random because mutations are equally likely at every locus.
