BIOC12H3 Lecture Notes - Lecture 10: Deprotonation, Carbohydrate Metabolism, Acylation

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Site directed mutagenesis: used to show significance of ser-his-asp catalytic triad. Cysteine proteases: cysteine residue activated by histidine, carries out a nucleophilic attack on the peptide, prof notes, papain has two important players, cysteine. If it is a cysteine protease, of course active player is cysteine: histidine. Aspartyl proteases: pair of aspartic residues act together in conjunction with water to attack the peptide bond, e. g. Hiv-1 / proteases / pepsin: prof notes. Important players: aspartate, common in hiv-1 / proteases / pepsin, one of the things to put into hiv is a protease inhibitor cocktail. Inhibits ability of virus to infect other cells. Cofactors and co-enzymes: often ignore cofactors and coenzymes because they complicate things, many enzymes need cofactors for catalysis, these cofactors are often required to convert inactive enzymes to active enzymes. Another example of essential ion cofactors: restriction endonucleases made by bacteria that cleave foreign dna are enzymes that require.

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