BIOC12H3 Lecture Notes - Lecture 2: Sodium Dodecyl Sulfate, Micelle, Monolayer
Document Summary
Lecture 2 water/ph and primary structure of proteins (topic 2 continued) cellular concentration and molecular crowding: assume we are looking at the path of a single water molecule throughout the cytoplasm. 10 times longer to cross the cell due to viscosity, interactions, and collisions. If water was the only thing in the cytoplasm. In-vivo cytoplasm with molecules and organelles: the water molecule will also interact with other charged molecules, and in the actual (b) situation, structures form and enzymes operate => water is critical for this process. For comparison, the dissociation energy of a covalent bond is. There are weak on their own, but together create a strong stable molecule! The effect is even more pronounced for larger polypeptides. Proteins a and b have a very strong interaction due to the variety of non-covalent forces (stable) In this case, the two proteins have fewer non-covalent forces between them, so the nature of their connection is transient.