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19 Dec 2011
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Lecture 13: c14: cognitive disorder : moving from an analysis from normal behaviours to the study of the genetics behind difference in personality and sexual behaviour of some of the most studied cognitive disorders in behaviours. In humans, mutation affecting the length of dopamine receptor 4 gene: long gene: increased interest in novel situations in personality tests. Example from the text book: describes this existing in dogs and different genes that have different levels in aggression, trainability. Main example: golden retriever versus a shiba (hard to train, low play-fullness, high aggression). Drd4 allele in dogs is opposite that the one in human. This polymorphism was found using genotyping by one group quite a while ago. Sometimes, we don"t understand what the polymorphism is doing. In dogs, the polymorphism is found, but we don"t know the functional differences and how they contribute to the phenotype, all we know that these allelic variations are associated with different phenotypes.

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