BIOC15H3 Lecture Notes - Lecture 3: Phenylalanine Hydroxylase, Nonsense Mutation, Frameshift Mutation
18 Nov 2013
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Insertion block of one or more nucleotide pairs is inserted into dna. Inversion 180 degree rotations of segment of dna molecule. Alkaptonuria: mutations in homogenistic oxidase gene (hgo) result in a deficiency of the enzyme ha oxidase and the accumulation of homogenistic acid, homogenisitc acid builds up and thus turns urine black. 2: mutations = dna damage dna repair, most times the mutation is repaired. Lethal gene mutations some mutations we are not able to find because it kills the organism which has the mutation. Clb chromosome: 1928 muller devised method of searching for any lethal mutation on the x chromosome (chromosome i in. If the paternal x chromosome in any one f1 female has an xray induced recessive lethal mutation she can produce only bar-eyed sons (left) If the x chrosmosome has no such mutation, this f1 female produces both bar eyed and non bar eyes sonsa (right) Mutation hunt or screen: choice of mutagen, fruit flies.
