BIOC17H3 Lecture Notes - Lecture 7: Immunoglobulin G, Aureus, Complement Component 5A
5 Oct 2017
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Capsule-mediated adherence is an important determinant of virulence: ex: entero pathogenic e. coli (epec) adheres to tissue, ex: vibrio cholera adheres to intestinal epithelial cells. Non adherent bacteria can be removed by host defences mechanisms: washed away, peristalsis, ciliary movement, fluid flow, shredding of epithelial cells, mucous layers, pathogens attach to target tissues and cells release toxins and other virulence factors. Glycocalyx adherence to surface and trapping water (what is the purpose of slide 14?) It will tap and transmit structure of bacteria on computer. Interaction activates the phagocyte to ingest and destroy pathogen and produce cytokines that activate other cells. Recognition for phagocytosis: pathogenic cells are marked with opsonins or complement phagocytosis recognition. Phagocytosis video: pipette has neutrophil, attaches to a bead through phagocytosis because bead is covered with opsonin proteins. Neutrophil will think its bacteria and eat it.
