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Lecture

BIOC33H3 Lecture Notes - Valsalva Maneuver, Heparin, Cerebral Circulation


Department
Biological Sciences
Course Code
BIOC33H3
Professor
Stephen Reid

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Chapter 34:Coronary Artery Disease and Acute Coronary Syndrome
Coronary artery disease (CAD) is a type of blood vessel disorder included in the
general category of atherosclerosis.
Atherosclerosis is characterized by a focal deposit of cholesterol and lipids within the
intimal wall of the artery. Inflammation and endothelial injury play a central role in the
development of atherosclerosis.
CAD is a progressive disease that develops in stages and when it becomes symptomatic,
the disease process is usually well advanced.
Normally some arterial anastomoses or connections, termed collateral circulation, exist
within the coronary circulation. The growth and extent of collateral circulation are
attributed to two factors: (1) the inherited predisposition to develop new blood vessels
(angiogenesis), and (2) the presence of chronic ischemia.
Many risk factors have been associated with CAD.
o Nonmodifiable risk factors are age, gender, ethnicity, family history, and genetic
inheritance.
o Modifiable risk factors include elevated serum lipids, hypertension, tobacco use,
physical inactivity, obesity, diabetes, metabolic syndrome, psychologic states, and
homocysteine level.
Elevated serum lipid levels are one of the four most firmly established risk
factors for CAD.
Lipids combine with proteins to form lipoproteins and are vehicles for fat
mobilization and transport. The different types of lipoproteins are
classified as high-density lipoproteins (HDLs), low-density lipoproteins
(LDLs), and very-low-density lipoproteins (VLDLs).
HDLs carry lipids away from arteries and to the liver for
metabolism. High serum HDL levels are desirable.
HDL levels are increased by physical activity, moderate alcohol
consumption, and estrogen administration.
Elevated LDL levels correlate most closely with an increased
incidence of atherosclerosis and CAD.
Hypertension, defined as a BP greater than or equal to 140/90 mm Hg, is a
major risk factor in CAD.
Tobacco use is also a major risk factor in CAD. The risk of developing
CAD is two to six times higher in those who smoke tobacco than in those
who do not.
Obesity is defined as a body mass index (BMI) of less than 30 kg/m2. The
increased risk for CAD is proportional to the degree of obesity.
o Diabetes, metabolic syndrome, and certain behavioral states (i.e., stress) have also
been found to be contributing risk factors for CAD.
CORONARY ARTERY DISEASE
Prevention and early treatment of CAD must involve a multifactorial approach and needs
to be ongoing throughout the lifespan
A complete lipid profile is recommended every 5 years beginning at age 20. Persons with
a serum cholesterol level greater than 200 mg/dl are at high risk for CAD.

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Management of high-risk persons starts with controlling or changing the additive effects
of modifiable risk factors.
o A regular physical activity program should be implemented.
o Therapeutic lifestyle changes to reduce the risk of CAD include lowering LDL
cholesterol by adopting a diet that limits saturated fats and cholesterol and
emphasizes complex carbohydrates (e.g., whole grains, fruit, vegetables).
o Low-dose aspirin is recommended for people at risk for CAD. Aspirin therapy is
not recommended for women with low risk for CAD before age 65. Common side
effects of aspirin therapy include GI upset and bleeding. For people who are
aspirin intolerant, clopidogrel (Plavix) can be considered.
If levels remain elevated despite modifiable changes, drug therapy is considered.
o Statin drugs work by inhibiting the synthesis of cholesterol in the liver. Liver
enzymes must be regularly monitored.
o Niacin, a water-soluble B vitamin, is highly effective in lowering LDL and
triglyceride levels by interfering with their synthesis. Niacin also increases HDL
levels better than many other lipid-lowering drugs.
o Fibric acid derivatives work by accelerating the elimination of VLDLs and
increasing the production of apoproteins A-I and A-II.
o Bile-acid sequestrants increase conversion of cholesterol to bile acids and
decrease hepatic cholesterol content. The primary effect is a decrease in total
cholesterol and LDLs.
o Certain drugs selectively inhibit the absorption of dietary and biliary cholesterol
across the intestinal wall.
The incidence of cardiac disease is greatly increased in the elderly and is the leading
cause of death in older persons. Strategies to reduce CAD risk are effective in this age
group but are often underprescribed.
Aggressive treatment of hypertension and hyperlipidemia will stabilize plaques in the
coronary arteries of older adults, and cessation of tobacco use helps decrease the risk for
CAD at any age.
CHRONIC STABLE ANGINA
Chronic stable angina refers to chest pain that occurs intermittently over a long
period with the same pattern of onset, duration, and intensity of symptoms.
o Angina is rarely sharp or stabbing, and it usually does not change with
position or breathing. Many people with angina complain of indigestion or a
burning sensation in the epigastric region.
o Anginal pain usually lasts for only a few minutes (3 to 5 minutes) and
commonly subsides when the precipitating factor is relieved. Pain at rest is
unusual.
The treatment of chronic stable angina is aimed at decreasing oxygen demand and/or
increasing oxygen supply and reducing CAD risk factors.
o In addition to antiplatelet and cholesterol-lowering drug therapy, the most
common drugs used to manage chronic stable angina are nitrates.
Short-acting nitrates are first-line therapy for the treatment of angina.
Nitrates produce their principal effects by dilating peripheral blood
vessels, coronary arteries, and collateral vessels.
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