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Lecture

BIOC33H3 Lecture Notes - Striatum, Benzodiazepine, Muscle Relaxant


Department
Biological Sciences
Course Code
BIOC33H3
Professor
Stephen Reid

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Chapter 59: Chronic Neurologic Problems
HEADACHE
The primary classifications of headaches include tension-type, migraine, and cluster headaches.
o Tension-type headache, the most common type of headache, is characterized by its
bilateral location and pressing/tightening quality. Tension-type headaches are usually of
mild or moderate intensity and not aggravated by physical activity.
o Migraine headache is a recurring headache characterized by unilateral or bilateral
throbbing pain, a triggering event or factor, strong family history, and manifestations
associated with neurologic and autonomic nervous system dysfunction.
o Cluster headaches are a rare form of headache with a sharp stabbing pain. Cluster
headaches involve repeated headaches that can occur for weeks to months at a time,
followed by periods of remission.
Therapies used in the treatment of headaches include drugs, meditation, yoga, biofeedback,
cognitive-behavioral therapy, and relaxation training.
Drug therapies include:
o Tension-type: nonopioid analgesic is used alone or in combination with a sedative,
muscle relaxant, tranquilizer, or codeine.
o Migraine: analgesic, triptans, and preventive treatment (i.e., topiramate).
o Cluster: drug therapy is not as useful as it is for the other types of headaches;
prophylactic drugs may be prescribed.
Headaches may be related to an inability to cope with daily stresses. The most effective therapy
may be to help patients examine their lifestyle, recognize stressful situations, and learn to cope
with them more appropriately.
In addition to using analgesics and analgesic combination drugs for the symptomatic relief of
headache, the patient should be encouraged to use relaxation techniques because they are
effective in relieving tension-type and migraine headaches.
SEIZURE DISORDERS AND EPILEPSY
Seizure is a paroxysmal, uncontrolled electrical discharge of neurons in the brain that interrupts
normal function. Seizures are often symptoms of an underlying illness.
Epilepsy is a condition in which a person has spontaneously recurring seizures caused by a
chronic underlying condition.

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Seizures are divided into two major classes: generalized and partial.
Generalized seizures involve both sides of the brain and are characterized by bilateral
synchronous epileptic discharges in the brain from the onset of the seizure. Because the entire
brain is affected at the onset of the seizures, there is no warning or aura.
o Tonic-clonic seizure is characterized by loss of consciousness and falling to the ground if
the patient is upright, followed by stiffening of the body (tonic phase) for 10 to 20
seconds and subsequent jerking of the extremities (clonic phase) for another 30 to 40
seconds.
o Absence (petit mal) seizure usually occurs only in children and rarely continues beyond
adolescence.
o Atypical absence seizure, which is characterized by a staring spell accompanied by other
signs and symptoms, includes brief warnings, peculiar behavior during the seizure, or
confusion after the seizure.
Partial seizures, also referred to as partial focal seizures, are caused by focal irritations. They
manifest with unilateral manifestations that arise from localized brain involvement.
o Simple partial seizures with elementary symptoms do not involve loss of consciousness
and rarely last longer than 1 minute.
o Complex partial seizures can involve a variety of behavioral, emotional, affective, and
cognitive functions. These seizures usually last longer than 1 minute and are frequently
followed by a period of postictal confusion.
Status epilepticus is a state of continuous seizure activity or a condition in which seizures recur in
rapid succession without return to consciousness between seizures. It is the most serious
complication of epilepsy and is a neurologic emergency.
Most seizures do not require professional emergency medical care because they are self-limiting
and rarely cause bodily injury. However, if status epilepticus occurs, if significant bodily harm occurs,
or if the event is a first-time seizure, medical care should be sought immediately.
Seizure disorders are treated primarily with antiseizure drugs. Therapy is aimed at preventing
seizures because cure is not possible.
A significant number of patients whose epilepsy cannot be controlled with drug therapy are
candidates for surgical intervention to remove the epileptic focus or prevent spread of epileptic
activity in the brain.
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