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Lecture 5

BIOC34H3 Lecture Notes - Lecture 5: Proximal Tubule, Whole Blood, Alkalosis


Department
Biological Sciences
Course Code
BIOC34H3
Professor
Stephen Reid
Lecture
5

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BIOC34H3
Winter 2017
Activity 1: Hyperventilation
Activity 2: Rebreathing Provide the data recorded from the experiments in this section
Activity 3: Renal Responses to Respiratory Acidosis and Alkalosis
Activity 4: Respiratory Responses to Metabolic Acidosis and Alkalosis
Questions
1.Drugs such as SIDS or DIDS block the activity of chloride-bicarbonate exchangers. Illustrate, on
a pH-bicarbonate (Davenport) diagram, the effects (on acid-base balance) of adding SIDS or DIDS
to the proximal tubule epithelial cells in the kidneys. Explain your diagram.
Due to the blockage in the chloride-bicarbonate exchanger of the proximal tubule, the bicarbonate
reabsorption from the kidneys into the blood is very little, or none. If this drug blocks the activity of
chloride-bicarbonate exchangers, blood bicarbonate levels would decrease, leading to acidosis in the
blood and the kidney will undergo metabolic alkalosis as bicarbonate increases in the kidney cells. The
Davenport Diagram clearly indicates that that the position is shifted from normal blood point to point 2
(along the pCO2 isobar i.e., no change in pCO2). This indicates a reduction in the pH and in bicarbonate
levels.
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