BIOC39H3 Lecture Notes - Lecture 3: Mutation, Exonuclease, V(D)J Recombination

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Lecture 3: antibody structure and generation of ig diversity. Recognition mechanisms of innate vs. adaptive immune system. Innate: recognize conserved pamps or altered self, fixed repertoire of cell surface and soluble molecules, receptors germline encoded (inherited from one generation to the next) Adaptive: cell surface receptors of single molecular type(b cell, t cell), almost infinite repertoire, receptors somatically encoded. B lymphocytes and t lymphocytes are cells of the adaptive immune system. Secreted antibody is of the same specificity as membrane ig (bcr: antibody repertoire= total number of different specific antibodies that can be made by an individual approximately 109 (10,000,000,000) Light chain= vl and cl: heavy chain= vh and ch1, ch2, ch3, (ch4, three globular domains= two fabs + one f, each composed of 4 ig domains. Ig-like domains common in cell-surface and secreted proteins of the immune system- immunoglobulin superfamily.

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